Hydrochloric Acid → HCID 67419789, compound
Reaction equation
[F:1][CH2:2][CH2:3][C:4]1([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[C:14]([C:26]([F:29])([F:28])[F:27])[CH:13]=2)[CH2:8][O:7]C(C)=[N:5]1.[ClH:30]>C(O)C>[ClH:30].[NH2:5][C:4]([CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[C:14]([C:26]([F:27])([F:28])[F:29])[CH:13]=1)([CH2:3][CH2:2][F:1])[CH2:8][OH:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
Compound 22-1 (400 mg) was dissolved in ethanol (10 ml), concentrated hydrochloric acid (2 ml) was added, and the mixture was stirred at 70° C. for 4.5 hr. The reaction mixture was concentrated, and the residue was washed with diisopropyl ether to give the object product (360 mg) as a white powder.
Workup
- concentrationThe reaction mixture was concentrated
- washthe residue was washed with diisopropyl ether
Sources & evidence
- ORD record
- ord-6358c13442404b2a8c985f8c7c721fcf
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08809304B2
Reaction notes
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