HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-fluoro-2-nitrophenoxy)tetrahydro-2H-pyran → 4-Fluoro-2-(oxan-4-yloxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-fluoro-2-nitrophenoxy)tetrahydro-2H-pyran | HCID 53352180 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Fluoro-2-(oxan-4-yloxy)aniline | HCID 58413079 | — |
Reaction Steps
4-(5-Fluoro-2-nitrophenoxy)tetrahydro-2-H-pyran (8.4 g) was dissolved in ethylacetate (30 ml) and Pd/C (500 mg) was added. The reaction was hydrogenated at room temperature and 50 PSI. The mixture was concentrated in vacuo to give the intended product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648068B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-2cfdc8daddad4ec6982432969dae3fbe |
| Source note | uspto-grants-2014_02 |