Hydrochloric Acid → HCID 58413192, compound

HRID 240612Notes

Reaction equation

HRID 240612 reaction equation
Cl.C(OC([N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([O:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[NH:23][C:24]2[C:25]3[C:32]([CH3:33])=[C:31]([C:34]([OH:36])=[O:35])[S:30][C:26]=3[N:27]=[CH:28][N:29]=2)[CH2:10]1)=O)(C)(C)C>CO.O1CCOCC1>[F:22][C:20]1[CH:19]=[CH:18][C:17]([NH:23][C:24]2[C:25]3[C:32]([CH3:33])=[C:31]([C:34]([OH:36])=[O:35])[S:30][C:26]=3[N:27]=[CH:28][N:29]=2)=[C:16]([O:15][C@H:11]2[CH2:12][CH2:13][CH2:14][NH:9][CH2:10]2)[CH:21]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58413177HCID 58413177, compound

Product 1

HCID 58413192HCID 58413192, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

HCl in Methanol (4M; 0.250 ml) was added into a solution of 4-[2-((S)-1-tert-butoxycarbonyl-piperidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (50 mg) in dioxane (2.5 ml) at room temperature. The reaction was stirred over the weekend. The reaction mixture was purified by chromatography. The product was triturated from hot MeOH to give the intended product.

Workup

  1. customThe reaction mixture was purified by chromatography
  2. customThe product was triturated from hot MeOH
  3. customto give the intended product

Sources & evidence

ORD record
ord-11b3adb0f3634d058e2ca678b5bf01ec
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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