Hydrochloric Acid → HCID 58413028, compound

Participants

Reaction Steps

HCl in methanol (4M; 2.5 ml) was added into a suspension of (S)-3-[2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester (0.96 g) in methanol (10 ml). The reaction was stirred at room temperature for 3.5 h. The solvent was removed in vacuo and the residue co-evaporated with chloroform. The crude HCl salt was purified by chromatography.

Provenance & Evidence