Hydrochloric Acid → HCID 58413028, compound

HRID 240613Notes

Reaction equation

HRID 240613 reaction equation
Cl.C(OC([N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([O:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[NH:23][C:24]2[C:25]3[C:32]([CH3:33])=[C:31]([C:34](=[O:36])[NH2:35])[S:30][C:26]=3[N:27]=[CH:28][N:29]=2)[CH2:10]1)=O)(C)(C)C>CO>[F:22][C:20]1[CH:19]=[CH:18][C:17]([NH:23][C:24]2[C:25]3[C:32]([CH3:33])=[C:31]([C:34]([NH2:35])=[O:36])[S:30][C:26]=3[N:27]=[CH:28][N:29]=2)=[C:16]([O:15][C@H:11]2[CH2:12][CH2:13][CH2:14][NH:9][CH2:10]2)[CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58413218HCID 58413218, compound

Product 1

HCID 58413028HCID 58413028, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

HCl in methanol (4M; 2.5 ml) was added into a suspension of (S)-3-[2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester (0.96 g) in methanol (10 ml). The reaction was stirred at room temperature for 3.5 h. The solvent was removed in vacuo and the residue co-evaporated with chloroform. The crude HCl salt was purified by chromatography.

Workup

  1. customThe solvent was removed in vacuo
  2. customThe crude HCl salt was purified by chromatography

Sources & evidence

ORD record
ord-af470f0d1e844d5583c6cd3fcfef7292
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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