Hydrazine hydrate (1:1) → HCID 55281927, compound

HRID 2406141Notes

Reaction equation

HRID 2406141 reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[C:6]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][C:7]=2[N:8]=[CH:9][N:10]=1>CCO>[NH:2]([C:5]1[C:6]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][C:7]=2[N:8]=[CH:9][N:10]=1)[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58199536HCID 58199536, compound

Product 1

HCID 55281927HCID 55281927, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

Hydrazine monohydrate (0.21 mL; 4.34 mmol; 1.2 equiv) was added to a suspension of 4-chloro-5,6,7,8,9,10-hexahydrocycloocta[d]-pyrimidine (0.71 g; 3.62 mmol; 1.0 equiv) in 8 mL of EtOH. The reaction was heated at 60° C. overnight. The solid was filtered, washed with H2O and dried to give 4-hydrazino-5,6,7,8,9,10-hexahydrocycloocta[d]-pyrimidine as an off-white solid (0.42 g; 60% yield).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with H2O
  3. customdried

Sources & evidence

ORD record
ord-9210bafe6e5c46f7977c11ec841a28c9
Source dataset
uspto-grants-2014_08
Patent number
US08809347B2

Reaction notes

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