Succinic Acid → HCID 178457292, compound

HRID 2406152Notes

Reaction equation

[CH2:1]([N:4]([CH2:47][CH2:48][CH3:49])[C:5]([CH2:7][O:8][C:9](=[O:46])[CH2:10][CH2:11][NH:12][S:13]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([N:24]2[CH2:45][CH2:44][C:27]3([NH:31]/[C:30](=[N:32]/[C:33]([C:35]4[C:40]([NH2:41])=[N:39][C:38]([NH2:42])=[C:37]([Cl:43])[N:36]=4)=[O:34])/[NH:29][CH2:28]3)[CH2:26][CH2:25]2)=[O:23])[CH:17]=1)(=[O:15])=[O:14])=[O:6])[CH2:2][CH3:3].[C:50]([OH:57])(=[O:56])[CH2:51][CH2:52][C:53]([OH:55])=[O:54]>CC(O)C>[C:50]([OH:57])(=[O:56])[CH2:51][CH2:52][C:53]([OH:55])=[O:54].[CH2:47]([N:4]([CH2:1][CH2:2][CH3:3])[C:5]([CH2:7][O:8][C:9](=[O:46])[CH2:10][CH2:11][NH:12][S:13]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([N:24]2[CH2:45][CH2:44][C:27]3([NH:31]/[C:30](=[N:32]/[C:33]([C:35]4[C:40]([NH2:41])=[N:39][C:38]([NH2:42])=[C:37]([Cl:43])[N:36]=4)=[O:34])/[NH:29][CH2:28]3)[CH2:26][CH2:25]2)=[O:23])[CH:17]=1)(=[O:15])=[O:14])=[O:6])[CH2:48][CH3:49]

Participants

Conditions

Temperature: 20 °C

Procedure

0.536 g of 3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester (may be prepared as in Preparation 1) and 0.12 g succinic acid were dissolved in 15.25 g 2-propanol at 50° C. in a magnetically stirred glass vial. The solution was cooled to 20° C. and then stirred at this temperature overnight. The resulting suspension was filtered.

Workup

filtrationThe resulting suspension was filtered

Sources & evidence

ORD record: ord-ca8d7dcf84a34172a0b2700a4c87c9cb
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809340B2

Reaction notes

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