Diisopropylethylamine → HCID 178473575, compound

HRID 2406205Notes

Reaction equation

HRID 2406205 reaction equation
C(N(CC)C(C)C)(C)C.Cl[C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([CH3:21])[CH:19]=2)[N:14]=[C:13]([S:22][CH3:23])[N:12]=1.C[C:25]1[CH:30]=[CH:29][C:28]([N:31]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[NH2:32])=[CH:27][CH:26]=1>O1CCOCC1>[CH3:21][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]([S:22][CH3:23])[NH:12][C:11]2=[N:32][N:31]([C:28]1[CH:29]=[CH:30][CH:25]=[CH:26][CH:27]=1)[C:33]([O:35][CH2:36][CH3:37])=[O:34]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 67017224HCID 67017224, compoundHCID 71741718HCID 71741718, compound

Product 1

HCID 178473575HCID 178473575, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

N,N-Diisopropylethylamine (0.104 mL, 0.6 mmol) was added to a solution of 11b (0.071 g, 0.3 mmol) and 10a, (0.057 g, 0.3 mmol) in 5 mL of dioxane and the solution was heated at reflux for 48 h; during which a white precipitate fell out. The white slurry was filtered and the precipitate was washed with dioxane to give 12 as a white solid. (0.110 g, 100%). mp. 229.7° C.;

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 48 h
  3. filtrationThe white slurry was filtered
  4. washthe precipitate was washed with dioxane

Sources & evidence

ORD record
ord-53af200e20694ad0a333e3cb5032de6b
Source dataset
uspto-grants-2014_08
Patent number
US08809355B2

Reaction notes

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