2-(4-Methylphenyl)-9-phenylethynyl-2,6-dihydro[1,2,4]triazolo[4,3-c]-quinazoline-3,5-dione → 2-(4-Methylphenyl)-9-(2-phenylethyl)-2,6-dihydro[1,2,4]-triazolo[4,3-c]-quinazoline-3,5-dione

Participants

Reaction Steps

A catalytic amount of 10% Pd/C and 13a (20.0 mg, 0.0510 mmol) in a mixture of 2 mL of dichloromethane and 2 mL of methyl alcohol was stirred during 12 h under H2 at atmospheric pressure. The mixture was filtered through celite, washed with additionally methyl alcohol and triturated from ethyl alcohol to afford 14a (16 mg, 0.0404 mmol, 79%) as a white solid. mp: 303° C.;

Provenance & Evidence