Hydrochloric Acid → HCID 58413056, compound

HRID 240621Notes

Reaction equation

HRID 240621 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([O:14][C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:16]=2[NH:25][C:26]2[C:27]3[C:34]([CH3:35])=[C:33]([C:36]([NH2:38])=[O:37])[S:32][C:28]=3[N:29]=[CH:30][N:31]=2)[CH2:9]1)=O)(C)(C)C.Cl>ClCCl.O1CCOCC1>[CH3:35][C:34]1[C:27]2[C:26]([NH:25][C:16]3[CH:17]=[CH:18][C:19]([C:21]([F:22])([F:24])[F:23])=[CH:20][C:15]=3[O:14][C@H:10]3[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]3)=[N:31][CH:30]=[N:29][C:28]=2[S:32][C:33]=1[C:36]([NH2:38])=[O:37]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58413108HCID 58413108, compound

Product 1

HCID 58413056HCID 58413056, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

4-[2-((S)-1-tert-butoxycarbonyl-piperidin-3-yloxy)-4-trifluoromethyl-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide (77 mg) was dissolved in dichloromethane (1 ml) and HCl in dioxan (4M; 1.5 ml) was added. The reaction was stirred at room temperature for 1 h. The solvent was removed in vacuo and the residue was purfied by chromatography to give the inteded product.

Workup

  1. customThe solvent was removed in vacuo
  2. customto give the inteded product

Sources & evidence

ORD record
ord-d313bc39acec473d9fad246cb33b531a
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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