4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide → 4-[[(1R)-3-(4-Morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

HRID 2406211Notes

Reaction equation

HRID 2406211 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[S:12]([C:15]([F:18])([F:17])[F:16])(=[O:14])=[O:13].[N:19]1([CH2:25][CH2:26][C@@H:27]([NH2:36])[CH2:28][S:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[N:19]1([CH2:25][CH2:26][C@@H:27]([NH:36][C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=2[S:12]([C:15]([F:18])([F:17])[F:16])(=[O:14])=[O:13])[CH2:28][S:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 250584524-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamideHCID 25058453(R)-4-Morpholino-1-(phenylthio)-2-butylamine

Product 1

HCID 250584544-[[(1R)-3-(4-Morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

Procedure

The title compound was prepared from 4-fluoro-3-(trifluoromethylsulfonyl)-benzenesulfonamide and (R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamine using the procedure described for Intermediate 4. MS (ESI) m/e (M+H+): 553.6.

Sources & evidence

ORD record
ord-aad2e96c01c648aeaa6f5dac574f98c0
Source dataset
uspto-grants-2014_08
Patent number
US08809352B2

Reaction notes

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