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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2406211Generated: October 30, 2026

4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide → 4-[[(1R)-3-(4-Morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

https://huagongshe.com/reaction/2406211

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamideHCID 25058452—
Reactant(R)-4-Morpholino-1-(phenylthio)-2-butylamineHCID 25058453—
Product4-[[(1R)-3-(4-Morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]benzenesulfonamideHCID 25058454—

Reaction Steps

The title compound was prepared from 4-fluoro-3-(trifluoromethylsulfonyl)-benzenesulfonamide and (R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamine using the procedure described for Intermediate 4. MS (ESI) m/e (M+H+): 553.6.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08809352B2
Source datasetuspto-grants-2014_08
ORD IDord-aad2e96c01c648aeaa6f5dac574f98c0
Source noteuspto-grants-2014_08