Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → 4-{4-Chloro-2-[(S)-1-(2,2,2-trifluoro-acetyl)-piperidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate | HCID 2759834 | — |
| 반응물 | (S)-1-(3-(2-amino-5-chlorophenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone | HCID 58413042 | — |
| 생성물 | 4-{4-Chloro-2-[(S)-1-(2,2,2-trifluoro-acetyl)-piperidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester | HCID 58413216 | — |
반응 단계
Prepared analogously to example 65.1. from 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and (S)-1-(3-(2-amino-5-chlorophenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone. The temperature was 110° C. for 2 h and no purification with chromatography was necessarily.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08648068B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-f8253aaffd3d48ddbbe24614096a51d4 |
| 출처 메모 | uspto-grants-2014_02 |