2-Bromobenzyl bromide → 1-(2-bromobenzyl)piperidin-4-one

HRID 2406231Notes

Reaction equation

HRID 2406231 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[Br:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16]Br>>[Br:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 769652-Bromobenzyl bromideHCID 30848514-Piperidone hydrochloride

Product 1

HCID 246945421-(2-bromobenzyl)piperidin-4-oneYield 82.2%

Procedure

According to the procedure described for Intermediate 31, alkylation of 4-piperidone hydrochloride (1.0 g, 4.0 mmol) with 1-bromo-2-bromomethylbenzene (543 mg, 4.0 mmol) afforded the title compound (882 mg, 82% yield). HR-MS (m/z, MH+): measured 268.15

Sources & evidence

ORD record
ord-89c69dad4869476c83346721e7c59fb1
Source dataset
uspto-grants-2014_08
Patent number
US08809352B2

Reaction notes

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