HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzyl bromide → 1-(2-bromobenzyl)piperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzyl bromide | HCID 76965 | — |
| Reactant | 4-Piperidone hydrochloride | HCID 3084851 | — |
| Product | 1-(2-bromobenzyl)piperidin-4-one | HCID 24694542 | 82.2% |
Reaction Steps
According to the procedure described for Intermediate 31, alkylation of 4-piperidone hydrochloride (1.0 g, 4.0 mmol) with 1-bromo-2-bromomethylbenzene (543 mg, 4.0 mmol) afforded the title compound (882 mg, 82% yield). HR-MS (m/z, MH+): measured 268.15
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809352B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-89c69dad4869476c83346721e7c59fb1 |
| Source note | uspto-grants-2014_08 |