Hydrochloric Acid → Hydrochloric Acid

HRID 2406334Notes

Reaction equation

HRID 2406334 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[CH2:34][C:18]4([CH2:33][C:20]5([CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]5)[CH2:19]4)[O:17][C:14]3=[CH:15][N:16]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:35]>O1CCOCC1>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[CH2:34][C:18]4([CH2:33][C:20]5([CH2:21][CH2:22][NH:23][CH2:24][CH2:25]5)[CH2:19]4)[O:17][C:14]3=[CH:15][N:16]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:35]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 72194734HCID 72194734, compound

Product 2

HCID 313Hydrochloric AcidHCID 867012015-(4-Methylsulfonyl-phenyl)-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1'-cyclobutane-3',4''-piperidine]

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

5-(4-Methylsulfonyl-phenyl)-1″-tert-butoxycarbonyl-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1′-cyclobutane-3′,4″-piperidine] (0.30 g) dissolved in 4 M HCl in 1,4-dioxane (5 mL) is stirred at room temperature for 1 h. The solution is diluted with 1,4-dioxane and concentrated to give the title compound as HCl salt. LC (method 1): tR=0.66 min; Mass spectrum (ESI+): m/z=385 [M+H]+.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-18b8f580bc5c43c5b541669606ccfb67
Source dataset
uspto-grants-2014_08
Patent number
US08809361B2

Reaction notes

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