Sodium Hydroxide → HCID 58413081, compound

HRID 240642Notes

Reaction equation

HRID 240642 reaction equation
C([O:3][C:4]([C:6]1[S:28][C:9]2[N:10]=[CH:11][N:12]=[C:13]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=3[O:22][C@@H:23]3[CH2:27][CH2:26][O:25][CH2:24]3)[C:8]=2[C:7]=1[CH3:29])=[O:5])C.[OH-].[Na+]>CO>[F:21][C:18]1[CH:19]=[CH:20][C:15]([NH:14][C:13]2[C:8]3[C:7]([CH3:29])=[C:6]([C:4]([OH:5])=[O:3])[S:28][C:9]=3[N:10]=[CH:11][N:12]=2)=[C:16]([O:22][C@@H:23]2[CH2:27][CH2:26][O:25][CH2:24]2)[CH:17]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67395324HCID 67395324, compound

Product 1

HCID 58413081HCID 58413081, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-{4-Fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (150 mg) was dissolved in methanol (5 ml) and NaOH (1M; 1.9 ml) was added. The reaction was stirred over the weekend. The organic solvent was evaporated and the residue was neutralised with HCl. The resultant precipitate was filtered and dried.

Workup

  1. customThe organic solvent was evaporated
  2. filtrationThe resultant precipitate was filtered
  3. customdried

Sources & evidence

ORD record
ord-d2ffff2d4e2a4807b3df24265807649b
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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