Sodium Hydroxide → HCID 58413081, compound

Participants

Reaction Steps

4-{4-Fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (150 mg) was dissolved in methanol (5 ml) and NaOH (1M; 1.9 ml) was added. The reaction was stirred over the weekend. The organic solvent was evaporated and the residue was neutralised with HCl. The resultant precipitate was filtered and dried.

Provenance & Evidence