Potassium Carbonate → HCID 58413135, compound

Participants

Reaction Steps

Potassium carbonate (278 mg) was added to a solution of acetic acid (2S,4S)-4-[2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-1-methanesulfonyl-pyrrolidin-2-ylmethyl ester (360 mg) in MeOH (5 ml) and THF (2 ml). The reaction was stirred at room temperature for 90 h. 10% aq. KHSO4 was added and the resultant suspension was filtered. The filter cake was washed with dichloromethan and diethylether.

Provenance & Evidence