Potassium Carbonate → HCID 58413135, compound

HRID 240650Notes

Reaction equation

HRID 240650 reaction equation
C(=O)([O-])[O-].[K+].[K+].[C:7]([C:10]1[S:41][C:13]2[N:14]=[CH:15][N:16]=[C:17]([NH:18][C:19]3[CH:39]=[CH:38][C:37]([F:40])=[CH:36][C:20]=3[O:21][C@@H:22]3[CH2:26][N:25]([S:27]([CH3:30])(=[O:29])=[O:28])[C@H:24]([CH2:31][O:32]C(=O)C)[CH2:23]3)[C:12]=2[C:11]=1[CH3:42])(=[O:9])[NH2:8].OS([O-])(=O)=O.[K+]>CO.C1COCC1>[F:40][C:37]1[CH:38]=[CH:39][C:19]([NH:18][C:17]2[C:12]3[C:11]([CH3:42])=[C:10]([C:7]([NH2:8])=[O:9])[S:41][C:13]=3[N:14]=[CH:15][N:16]=2)=[C:20]([O:21][C@H:22]2[CH2:23][C@@H:24]([CH2:31][OH:32])[N:25]([S:27]([CH3:30])(=[O:29])=[O:28])[CH2:26]2)[CH:36]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 516920Potassium bisulfateHCID 58413193HCID 58413193, compound

Product 1

HCID 58413135HCID 58413135, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Potassium carbonate (278 mg) was added to a solution of acetic acid (2S,4S)-4-[2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-1-methanesulfonyl-pyrrolidin-2-ylmethyl ester (360 mg) in MeOH (5 ml) and THF (2 ml). The reaction was stirred at room temperature for 90 h. 10% aq. KHSO4 was added and the resultant suspension was filtered. The filter cake was washed with dichloromethan and diethylether.

Workup

  1. filtrationthe resultant suspension was filtered
  2. washThe filter cake was washed with dichloromethan and diethylether

Sources & evidence

ORD record
ord-26280513bf4149b6854ac90a464b37a5
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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