1-(2-Chloroethyl)pyrrolidine hydrochloride → HCID 66821881, compound

HRID 2406574Notes

Reaction equation

HRID 2406574 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:17])[CH2:14][CH2:15][CH3:16])=[CH:9][CH:8]=1)[CH3:2].Cl.ClCCN1CCCC1>>[N:3]1([CH2:4][CH2:5][O:6][C:7]2[CH:8]=[CH:9][C:10]([C:13](=[O:17])[CH2:14][CH2:15][CH3:16])=[CH:11][CH:12]=2)[CH2:1][CH2:2][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 816681-(2-Chloroethyl)pyrrolidine hydrochlorideHCID 668223691-(4-(2-(Diethylamino)ethoxy)phenyl)butan-1-one

Product 1

HCID 66821881HCID 66821881, compoundYield 87%

Procedure

The title compound was prepared by using a similar procedure as described for the preparation of 21 except that 1-(2-chloroethyl)pyrrolidine hydrochloride was used instead of 2-(diethylamino)ethyl chloride hydrochloride. This produced a crude oil, which was purified by flash silica gel column chromatography, eluting with 3:1 hexanes/ethyl acetate, to give 23 (455 mg, 87%) as a clear oil: MS (ES+) m/z 262.1 (M+H)+.

Workup

  1. customThe title compound was prepared
  2. customThis produced a crude oil, which
  3. customwas purified by flash silica gel column chromatography
  4. washeluting with 3:1 hexanes/ethyl acetate

Sources & evidence

ORD record
ord-235130c63587496dad397676562ae079
Source dataset
uspto-grants-2014_08
Patent number
US08809377B2

Reaction notes

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