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HRID 2406574作成日：2026年10月25日

1-(2-Chloroethyl)pyrrolidine hydrochloride → HCID 66821881、化合物

https://huagongshe.com/reaction/2406574

反応式

関与物質

役割名称HCID仕込み量
反応物1-(2-Chloroethyl)pyrrolidine hydrochlorideHCID 81668—
反応物1-(4-(2-(Diethylamino)ethoxy)phenyl)butan-1-oneHCID 66822369—
生成物HCID 66821881HCID 6682188187%

反応手順

The title compound was prepared by using a similar procedure as described for the preparation of 21 except that 1-(2-chloroethyl)pyrrolidine hydrochloride was used instead of 2-(diethylamino)ethyl chloride hydrochloride. This produced a crude oil, which was purified by flash silica gel column chromatography, eluting with 3:1 hexanes/ethyl acetate, to give 23 (455 mg, 87%) as a clear oil: MS (ES+) m/z 262.1 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08809377B2
出典データセットuspto-grants-2014_08
ORD IDord-235130c63587496dad397676562ae079
出典メモuspto-grants-2014_08