Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → HCID 66821978, Verbindung

HRID 2406575Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2406575
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:17])[CH2:14][CH2:15][CH3:16])=[CH:9][CH:8]=1)[CH3:2].Cl.ClCCN1CC[O:27]CC1>>[O:27]1[CH2:2][CH2:1][N:3]([CH2:4][CH2:5][O:6][C:7]2[CH:8]=[CH:9][C:10]([C:13](=[O:17])[CH2:14][CH2:15][CH3:16])=[CH:11][CH:12]=2)[CH2:18][CH2:19]1

Komponenten

3

Edukt 2

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 668223691-(4-(2-(Diethylamino)ethoxy)phenyl)butan-1-one

Produkt 1

HCID 66821978HCID 66821978, Verbindung

Versuchsvorschrift

The title compound was prepared by using a similar procedure as described for the preparation of 21 except that N-(2-chloroethyl)morpholine hydrochloride was used instead of 2-(diethylamino)ethyl chloride hydrochloride. This produced a crude oil, which was purified by silica gel column chromatography, eluting with 1:1 hexanes/ethyl acetate, to give 24 (550 mg, quantitative) as a clear oil: MS (ES+) m/z 278.1 (M+H)+.

Aufarbeitung

  1. customThe title compound was prepared
  2. customThis produced a crude oil, which
  3. customwas purified by silica gel column chromatography
  4. washeluting with 1:1 hexanes/ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-b3e9f37b32d5428fb6a15a4d04f85411
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809377B2

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