Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 1-(4-(2-Morpholinoethoxy)phenyl)butan-1-one

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The title compound was prepared by using a similar procedure as described for the preparation of 21 except that N-(2-chloroethyl)morpholine hydrochloride was used instead of 2-(diethylamino)ethyl chloride hydrochloride. This produced a crude oil, which was purified by silica gel column chromatography, eluting with 1:1 hexanes/ethyl acetate, to give 24 (550 mg, quantitative) as a clear oil: MS (ES+) m/z 278.1 (M+H)+.

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