1-(4-(2-Morpholinoethoxy)phenyl)butan-1-one → 1-(4-(2-Morpholinoethoxy)phenyl)butan-1-amine

HRID 2406579Notes

Reaction equation

HRID 2406579 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH:13]([NH2:17])[CH2:14][CH2:15][CH3:16])=[CH:9][CH:8]=1)[CH3:2].[O:20]1CCN(CCOC2C=CC(C(=O)CCC)=CC=2)CC1>>[O:20]1[CH2:2][CH2:1][N:3]([CH2:4][CH2:5][O:6][C:7]2[CH:8]=[CH:9][C:10]([CH:13]([NH2:17])[CH2:14][CH2:15][CH3:16])=[CH:11][CH:12]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 668219781-(4-(2-Morpholinoethoxy)phenyl)butan-1-oneHCID 66822143HCID 66822143, compound

Product 1

HCID 668220281-(4-(2-Morpholinoethoxy)phenyl)butan-1-amineYield 70%

Procedure

The title compound was prepared by using a similar procedure as described for the preparation of 25 except that 1-(4-(2-morpholinoethoxy)phenyl)butan-1-one (24) was used instead of 1-(4-(2-(diethylamino)ethoxy)phenyl)butan-1-one (21). This produced crude 28 (390 mg, 70%) as a light yellow oil: MS (ES+) m/z 279.2 (M+H)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-4e8b16aed365483ebb35b5009d3c7f78
Source dataset
uspto-grants-2014_08
Patent number
US08809377B2

Reaction notes

Loading…