HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-Phenylbutylamine → (S)-2-cyano-N-(1-phenylbutyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-Phenylbutylamine | HCID 2449444 | — |
| Reactant | 2-Cyano-N-(1-(4-(2-(diethylamino)ethoxy)phenyl)butyl)acetamide | HCID 66822019 | — |
| Product | (S)-2-cyano-N-(1-phenylbutyl)acetamide | HCID 66822152 | 58% |
Reaction Steps
The title compound was prepared by using a similar procedure as described for the preparation of 29 except that (S)-1-phenylbutylamine was used instead of 1-(4-(2-(diethylamino)ethoxy)phenyl)butan-1-amine (25). This produced crude product which was purified by flash silica gel column chromatography, eluting with 7:3 hexanes/ethyl acetate, to give 39 (375 mg, 58%) as a white solid: MS (ES+) m/z 217.1.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809377B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-2bbccb3301ad4c8a967df9b2b3cdb307 |
| Source note | uspto-grants-2014_08 |