1,2-Bis(2-iodoethoxy)ethane → HCID 66822250, compound

HRID 2406593Notes

Reaction equation

HRID 2406593 reaction equation
C(N(CC)[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:17])[CH2:14][CH2:15][CH3:16])=[CH:9][CH:8]=1)C.[I:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26]CCI>>[I:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:13](=[O:17])[CH2:14][CH2:15][CH3:16])=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 5934361,2-Bis(2-iodoethoxy)ethaneHCID 668223691-(4-(2-(Diethylamino)ethoxy)phenyl)butan-1-one

Product 1

HCID 66822250HCID 66822250, compound

Procedure

The title compound was prepared by using a similar procedure as described for the preparation of 21 except that 1,2-bis-(2-iodoethyloxy)ethane was used instead of 2-(diethylamino)ethyl chloride hydrochloride. This produced the crude product which was purified by flash silica gel column chromatography, eluting with 4:1 hexanes/ethyl acetate to give 43 (3.85 g, 52%) as a clear oil: MS (ES+) m/z 407.0 (M+H)+.

Workup

  1. customThis produced the crude product which

Sources & evidence

ORD record
ord-6f2225c5f80f4a8bb88d8e82ab96d4e3
Source dataset
uspto-grants-2014_08
Patent number
US08809377B2

Reaction notes

Loading…