4-Amino-1-methylpiperidine → 4-{4-Fluoro-2-[(S)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (1-methyl-piperidin-4-yl)-amide

HRID 240663Notes

Reaction equation

HRID 240663 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19](O)=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:27][CH2:26][O:25][CH2:24]2)[CH:3]=1.[CH3:28][N:29]1[CH2:34][CH2:33][CH:32]([NH2:35])[CH2:31][CH2:30]1>>[CH3:28][N:29]1[CH2:34][CH2:33][CH:32]([NH:35][C:19]([C:16]2[S:15][C:11]3[N:12]=[CH:13][N:14]=[C:9]([NH:8][C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=4[O:22][C@H:23]4[CH2:27][CH2:26][O:25][CH2:24]4)[C:10]=3[C:17]=2[CH3:18])=[O:20])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 58413126HCID 58413126, compound

Product 1

HCID 673975194-{4-Fluoro-2-[(S)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (1-methyl-piperidin-4-yl)-amide

Procedure

Prepared analogously to example 1.4 from 4-{4-fluoro-2-[(S)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and 1-methyl-piperidin-4-ylamine.

Sources & evidence

ORD record
ord-3f68f76cab134e37b7cbf57f36b37b3f
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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