反应详情

(R)-tert-butyl 2-((2-(2-Hydroxyethylcarbamoyl)Pyridin-3-Yloxy)Methyl)Pyrrolidine-1-Carboxylate (330 mg, 0.90 mmol, EXAMPLE 33 Step 3) was dissolved in 10% hydrogen chloride in methanol (8 mL) at room temperature. After being stirred at room temperature for 4 days, the volatile was evaporated to afford 304 mg (quant.) of the title compound that was used directly in the next step without further purification.

1. customthe volatile was evaporated