Indole-2-carboxylic acid → HCID 178470238, compound

HRID 2406824Notes

Reaction equation

HRID 2406824 reaction equation
[NH:1]1[CH2:5][CH2:4][CH:3]([CH2:6][O:7][C:8]2[C:9]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=2)[CH2:2]1.[F:19][C:20]([F:31])([F:30])[C@H:21]1[CH2:26][CH2:25][C@H:24]([C:27](O)=[O:28])[CH2:23][CH2:22]1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[F:19][C:20]([F:30])([F:31])[C@H:21]1[CH2:22][CH2:23][C@H:24]([C:27]([N:1]2[CH2:5][CH2:4][CH:3]([CH2:6][O:7][C:8]3[C:9]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=3)[CH2:2]2)=[O:28])[CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 66962066Ethyl 3-(pyrrolidin-3-ylmethoxy)picolinateHCID 178525710HCID 178525710, compound

Product 1

HCID 178470238HCID 178470238, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 1 using ethyl 3-(pyrrolidin-3-ylmethoxy)picolinate (EXAMPLE 92, Step 2) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-ff535d13bf6e4e4e94a81b2f199ea7ea
Source dataset
uspto-grants-2014_08
Patent number
US08809380B2

Reaction notes

Loading…