N-Aminomorpholine → 5-(4-chlorophenyl)-N-morpholino-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

HRID 240683Notes

Reaction equation

HRID 240683 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([OH:22])=O)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[N:23]1([NH2:29])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([NH:29][N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[O:22])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 20315N-AminomorpholineHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 712941665-(4-chlorophenyl)-N-morpholino-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and 4-morpholinamine (CAN 4319-49-7) as starting materials; LC-MS (UV peak area/ESI) 100%, 415.0911 (M−H)−.

Sources & evidence

ORD record
ord-1ceaa8e9241142ff963a7a3996aed01c
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

Loading…