反应详情

Following the same procedure as in Example 1, 13.8 g (0.1 mole) of 1-hydroxy-3,4-dimethoxybenzene, 13.8 g (0.1 mole) of anhydrous potassium carbonate in ml 50 of acetone and 14.9 g (0.1 mole) of a solution of propargyl bromide in toluene (80% w/w) were reacted. After work up and evaporation of the mixture u.v. (25° C./21 mbar) a residue was obtained that was purified on silica gel column (eluant n-hexane:ethyl acetate 5:1 v/v). A thick oil that after some time solidified with low melting point (28-30° C.) (b.p.: 109-110° C./ 3 mbar) was obtained whose NMR and MS analyses corresponded to those of the aforementioned compound.

1. customwere reacted
2. customAfter work up and evaporation of the mixture u.v
3. custom(25° C./21 mbar) a residue was obtained
4. customthat was purified on silica gel column (eluant n-hexane:ethyl acetate 5:1 v/v)
5. customsolidified with low melting point (28-30° C.) (b.p.: 109-110° C./ 3 mbar)
6. customwas obtained whose NMR and MS analyses