4-Amino-1lambda~6~,4-thiazinane-1,1-dione → 5-(4-chloro-phenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxamide

HRID 240684Notes

Reaction equation

HRID 240684 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([OH:22])=O)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[N:23]1([NH2:31])[CH2:28][CH2:27][S:26](=[O:30])(=[O:29])[CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([C:20]([NH:31][N:23]3[CH2:28][CH2:27][S:26](=[O:30])(=[O:29])[CH2:25][CH2:24]3)=[O:22])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 127082634-Amino-1lambda~6~,4-thiazinane-1,1-dioneHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 712940125-(4-chloro-phenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and 4-thiomorpholinamine 1,1-dioxide (CAN 26494-76-8) as starting materials; MS (EI) 464.1 (M+H)+.

Sources & evidence

ORD record
ord-ff76c3ccc7d54a6d90580bdd48967a90
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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