反应详情

Following the same procedure as in Example 2), a mixture of 4.0 g (0.029 moles) of 5-hydroxy-2,3-dihydrobenzofuran, 4.0 g (0.029 moles) of anhydrous potassium carbonate in ml 25 of acetone was added with 3.9 g (0.029 moles) of 1-bromo-2-butyne. The mixture was heated to reflux for 6 hrs. After cooling to room temperature, the mixture was filtered and the filtrate evaporated u.v (20° C./ 21 mbar). The residue so obtained was purified by chromatography on silica column (eluant n-hexane/ethyl acetate 5/1 (v/v))

1. temperatureThe mixture was heated
2. temperatureto reflux for 6 hrs
3. filtrationthe mixture was filtered
4. customthe filtrate evaporated u.v (20° C./ 21 mbar)
5. customThe residue so obtained
6. customwas purified by chromatography on silica column (eluant n-hexane/ethyl acetate 5/1 (v/v))