Amoz → 5-(4-chlorophenyl)-N-(5-(morpholinomethyl)-2-oxooxazolidin-3-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

HRID 240688Notes

Reaction equation

HRID 240688 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20](O)=[O:21])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[NH2:23][N:24]1[CH2:28][CH:27]([CH2:29][N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[O:26][C:25]1=[O:36]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([C:20]([NH:23][N:24]3[CH2:28][CH:27]([CH2:29][N:30]4[CH2:31][CH2:32][O:33][CH2:34][CH2:35]4)[O:26][C:25]3=[O:36])=[O:21])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 3016406AmozHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 712940095-(4-chlorophenyl)-N-(5-(morpholinomethyl)-2-oxooxazolidin-3-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and 3-amino-5-(4-morpholinylmethyl)-2-oxazolidinone (CAN 43056-63-9) as starting materials; LC-MS (UV peak area/ESI) 97.7%, 515.1292 (M+H)+.

Sources & evidence

ORD record
ord-777a1fd4f7c54c73908465ffaa5d2247
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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