3-Chloro-6-(1-methylhydrazinyl)pyridazine → 5-(4-chlorophenyl)-N'-(6-chloropyridazin-3-yl)-N'-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

HRID 240689Notes

Reaction equation

HRID 240689 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([OH:22])=O)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[Cl:23][C:24]1[N:25]=[N:26][C:27]([N:30]([CH3:32])[NH2:31])=[CH:28][CH:29]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([C:20]([NH:31][N:30]([C:27]3[N:26]=[N:25][C:24]([Cl:23])=[CH:29][CH:28]=3)[CH3:32])=[O:22])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:18])([F:19])[F:17])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27358153-Chloro-6-(1-methylhydrazinyl)pyridazineHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 715097085-(4-chlorophenyl)-N'-(6-chloropyridazin-3-yl)-N'-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and 3-chloro-6-(1-methylhydrazinyl)-pyridazine (CAN 76953-33-8) as starting materials; LC-MS (UV peak area/ESI) 96.8%, 472.0538 (M+H)+.

Sources & evidence

ORD record
ord-1465b9a1978c4e9e99f714963ac1051e
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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