4-Chlorophenylboronic acid → 5-(4-Chlorophenyl)-6-cyclobutoxy-nicotinic acid

HRID 240694Notes

Reaction equation

HRID 240694 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[CH:5]=[N:6][C:7]=1[O:8][CH:9]1[CH2:12][CH2:11][CH2:10]1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[CH:5]=[N:6][C:7]=2[O:8][CH:9]2[CH2:12][CH2:11][CH2:10]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 66678843HCID 66678843, compound

Product 1

HCID 666786185-(4-Chlorophenyl)-6-cyclobutoxy-nicotinic acid

Procedure

The title compound was synthesized in analogy to Example 9a using 5-bromo-6-cyclobutoxy-3-pyridinecarboxylic acid and B-(4-chlorophenyl)-boronic acid (CAN 1679-18-1) as starting materials; MS (ESI): 302.2 (M−H)−.

Sources & evidence

ORD record
ord-2baddf57ed2e4675811c4ade997971cc
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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