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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240694Generated: October 30, 2026

4-Chlorophenylboronic acid → 5-(4-Chlorophenyl)-6-cyclobutoxy-nicotinic acid

https://huagongshe.com/reaction/240694

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chlorophenylboronic acidHCID 74299—
Reactant5-Bromo-6-cyclobutoxynicotinic acidHCID 66678843—
Product5-(4-Chlorophenyl)-6-cyclobutoxy-nicotinic acidHCID 66678618—

Reaction Steps

The title compound was synthesized in analogy to Example 9a using 5-bromo-6-cyclobutoxy-3-pyridinecarboxylic acid and B-(4-chlorophenyl)-boronic acid (CAN 1679-18-1) as starting materials; MS (ESI): 302.2 (M−H)−.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648099B2
Source datasetuspto-grants-2014_02
ORD IDord-2baddf57ed2e4675811c4ade997971cc
Source noteuspto-grants-2014_02