反应详情

Cholanic acid (3.6 g, 10.0 mmoles) is suspended in methylene chloride (200 mL) and stirred well at ambient temperature. 4-Nitrophenol (1.4 g, 10.1 mmoles) and N,N′-dicylcohexylcarbodiimide (2.1 g, 10.2 mmoles) are added, and the mixture is stirred overnight. The mixture is then filtered, the solid washed with a little methylene chloride, and the filtrate is evaporated to dryness to give a yellow solid. The crude product is dissolved in ethyl acetate (100 mL). The solution is filtered and the filtrate si evaporated to give an off-white solid. The solid is crystallized from hot hexanes. The yield is 3.9 g (80%).

1. stirringthe mixture is stirred overnight
2. filtrationThe mixture is then filtered
3. washthe solid washed with a little methylene chloride
4. customthe filtrate is evaporated to dryness
5. customto give a yellow solid
6. filtrationThe solution is filtered
7. customthe filtrate si evaporated
8. customto give an off-white solid
9. customThe solid is crystallized from hot hexanes