3-Chloro-6-(1-methylhydrazinyl)pyridazine → N'-(6-chloropyridazin-3-yl)-5-cyclopentyl-N'-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

HRID 240706Notes

Reaction equation

HRID 240706 reaction equation
[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([OH:20])=O)[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:21][C:22]1[N:23]=[N:24][C:25]([N:28]([CH3:30])[NH2:29])=[CH:26][CH:27]=1>>[Cl:21][C:22]1[N:23]=[N:24][C:25]([N:28]([CH3:30])[NH:29][C:18]([C:8]2[CH:9]=[N:10][C:11]([O:12][CH2:13][C:14]([F:15])([F:16])[F:17])=[C:6]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)[CH:7]=2)=[O:20])=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 27358153-Chloro-6-(1-methylhydrazinyl)pyridazineHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 71510017N'-(6-chloropyridazin-3-yl)-5-cyclopentyl-N'-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 14c) and 3-chloro-6-(1-methylhydrazinyl)-pyridazine (CAN 76953-33-8) as starting materials; MS (EI) 430.4 (M+H)+.

Sources & evidence

ORD record
ord-865ea78e6f4f477fbe3e3d69dc9205ac
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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