2,4-Difluorophenylglyoxal hydrate → as-Triazine, 5-(2,4-difluorophenyl)-3-(methylthio)-

HRID 2407079Notes

Reaction equation

[NH:1]([C:3]([S:5][CH3:6])=[NH:4])[NH2:2].O.[F:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16]([CH:18]=O)=O>>[CH3:6][S:5][C:3]1[N:1]=[N:2][CH:18]=[C:16]([C:10]2[CH:11]=[CH:12][C:13]([F:15])=[CH:14][C:9]=2[F:8])[N:4]=1

Participants

Reactant 2

HCID 27823002,4-Difluorophenylglyoxal hydrate

HCID 178504051Methyl hydrazinecarbimidothioate

Product 1

HCID 3053040as-Triazine, 5-(2,4-difluorophenyl)-3-(methylthio)-Yield 78%

Procedure

3-(Methylsulfanyl)-5-(2,4-difluorophenyl)-1,2,4-triazine (1.00 g, 78%) was prepared from methyl hydrazinecarbimidothioate (0.63 g, 6.0 mmol) and 2,4-difluorophenylglyoxal monohydrate (1.00 g, 6.0 mmol) according to the general procedure of Preparation 2.

Workup

customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record: ord-19e9a95df52b4444833f118177382581
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809525B2

Reaction notes

Loading…