146535-00-4 → HCID 67365291, compound

HRID 2407089Notes

Reaction equation

HRID 2407089 reaction equation
[NH:1]([C:3]([S:5][CH3:6])=[NH:4])[NH2:2].[F:7][C:8]1[CH:9]=[C:10]([C:15](=O)[CH:16]=O)[CH:11]=[C:12]([F:14])[CH:13]=1>>[CH3:6][S:5][C:3]1[N:1]=[N:2][CH:16]=[C:15]([C:10]2[CH:9]=[C:8]([F:7])[CH:13]=[C:12]([F:14])[CH:11]=2)[N:4]=1

Participants

3

Reactant 2

HCID 18784701146535-00-4HCID 178504051Methyl hydrazinecarbimidothioate

Product 1

HCID 67365291HCID 67365291, compoundYield 80%

Procedure

3-(methylsulfanyl)-5-(3,5-difluorophenyl)-1,2,4-triazine (28 g, 80.0%) was prepared from methyl hydrazine carbimidothioate (20.68 g, 197.4 mmol) and 2-(3,5-difluorophenyl)-2-oxoacetaldehyde (25 g, 147.0 mmol) according to the general procedure of Preparation 2.

Workup

  1. customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record
ord-abb464f8b92d43a282bb3435d245e5c4
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

Loading…