5-Chloro-2-methoxyphenylboronic acid → 6-(5-Chloro-2-methoxyphenyl)-5-phenyl-1,2,4-triazin-3-amine

HRID 2407103Notes

Reaction equation

HRID 2407103 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([O:25][CH3:26])=[C:20](B(O)O)[CH:21]=1>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([O:25][CH3:26])=[C:18]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 27357515-Chloro-2-methoxyphenylboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 533545236-(5-Chloro-2-methoxyphenyl)-5-phenyl-1,2,4-triazin-3-amineYield 22.8%

Procedure

6-(5-Chloro-2-methoxyphenyl)-5-phenyl-1,2,4-triazin-3-amine (57 mg, 22%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.21 g, 0.80 mmol) and 5-chloro-2-methoxyphenylboronic acid (0.15 g, 0.80 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-985847a93c444ce581dd66d497e6e47a
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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