2,6-Dimethylmorpholine → HCID 53354627, compound

HRID 2407143Notes

Reaction equation

HRID 2407143 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:15][CH:16]1[O:21][CH:20]([CH3:22])[CH2:19][NH:18][CH2:17]1>>[CH3:22][CH:20]1[O:21][CH:16]([CH3:15])[CH2:17][N:18]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:19]1

Participants

3

Reactant 2

HCID 1108622,6-DimethylmorpholineHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53354627HCID 53354627, compoundYield 10.3%

Procedure

6-(2,6-Dimethylmorpholin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (35 mg, 10%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.30 g, 1.19 mmol) and 2,6-dimethylmorpholine (0.27 g, 2.39 mmol) according to the general procedure of Example 2.

Sources & evidence

ORD record
ord-74610651eb7b42d9b600e4128b8da4b2
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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