3-(Trifluoromethyl)piperidine → HCID 53353230, compound

HRID 2407146Notes

Reaction equation

HRID 2407146 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]([F:24])([F:23])[CH:17]1[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]1>>[C:9]1([C:3]2[N:4]=[C:5]([NH2:8])[N:6]=[N:7][C:2]=2[N:19]2[CH2:20][CH2:21][CH2:22][CH:17]([C:16]([F:24])([F:23])[F:15])[CH2:18]2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 27607763-(Trifluoromethyl)piperidineHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353230HCID 53353230, compoundYield 8%

Procedure

5-Phenyl-6-[3-(trifluoromethyl)piperidin-1-yl]-1,2,4-triazin-3-amine (50 mg, 8%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.50 g, 1.99 mmol) and 3-(trifluoromethyl)piperidine (0.40 g, 2.58 mmol) according to the general procedure of Example 2.

Sources & evidence

ORD record
ord-45830f49c8d44b259f40c4570e965cf9
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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