Potassium Carbonate → HCID 53353903, compound

HRID 2407148Notes

Reaction equation

HRID 2407148 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C([O-])([O-])=O.[K+].[K+].Cl.[CH3:22][O:23][CH:24]1[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]1>>[CH3:22][O:23][CH:24]1[CH2:29][CH2:28][CH2:27][N:26]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:25]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 231420003-Methoxypiperidine--hydrogen chloride (1/1)HCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353903HCID 53353903, compoundYield 4.2%

Procedure

6-(3-Methoxypiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amine (33 mg, 4%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.70 g, 2.78 mmol), K2CO3 (0.80 g, 5.85 mmol) and 3-methoxy piperidine HCl (0.52 g, 3.34 mmol) according to the general procedure of Example 2.

Sources & evidence

ORD record
ord-eb38becbf25f42a8888a0921d2a56d22
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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