3-Ethynylpiperidine hydrochloride → 6-(3-Ethynylpiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amine

HRID 2407149Notes

Reaction equation

HRID 2407149 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl.[C:16]([CH:18]1[CH2:23][CH2:22][CH2:21][NH:20][CH2:19]1)#[CH:17]>>[C:16]([CH:18]1[CH2:23][CH2:22][CH2:21][N:20]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:19]1)#[CH:17]

Participants

3

Reactant 2

HCID 534011233-Ethynylpiperidine hydrochlorideHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 533539046-(3-Ethynylpiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amineYield 2%

Procedure

6-(3-Ethynylpiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amine (10 mg, 2%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.60 g, 2.40 mmol) and 3-ethynyl piperidine HCl (0.42 g, 2.87 mmol) according to the general procedure of Example 2.

Sources & evidence

ORD record
ord-a339a2df046046309a77c0a5dbbc14c3
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

Loading…