2,6-Dimethylmorpholine → HCID 53353905, compound

HRID 2407150Notes

Reaction equation

HRID 2407150 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1.[CH3:16][CH:17]1[O:22][CH:21]([CH3:23])[CH2:20][NH:19][CH2:18]1>>[CH3:23][CH:21]1[O:22][CH:17]([CH3:16])[CH2:18][N:19]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH2:20]1

Participants

3

Reactant 2

HCID 1108622,6-DimethylmorpholineHCID 86676117HCID 86676117, compound

Product 1

HCID 53353905HCID 53353905, compoundYield 20%

Procedure

6-(2,6-Dimethylmorpholin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (110 mg, 20%) was prepared from 6-bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (0.50 g, 1.87 mmol) and 2,6-dimethylmorpholine (1.06 g, 9.36 mmol) according to the general procedure of Example 2.

Sources & evidence

ORD record
ord-1a7b9253c3e143f39beab1e245a608c4
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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