Trifluoroacetic acid → 4-(2-((Tert-butyldimethylsilyl)oxy)ethyl)piperidin-1-amine 2,2,2-trifluoroacetate

Participants

Reaction Conditions

Reaction Steps

{4-[2-(t-Butyl-dimethyl-silanyloxy)-ethyl]-piperidin-1-yl}-carbamic acid t-butyl ester (168 mg, 468 μmol) was at 0° C. combined with dichloromethane (2 mL) and trifluoroacetic acid (2 mL) to give a light yellow solution. The reaction mixture was stirred for 2 h at 0° C. and subsequently concentrated in vacuo to give the title compound as yellow oil, which was used without further purification in the next step.

Provenance & Evidence