Phenol → HCID 67362736, compound

HRID 2407170Notes

Reaction equation

HRID 2407170 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:14]2[CH:15]=[C:16]([OH:25])[CH:17]=[C:18]([O:20][C:21]([F:24])([F:23])[F:22])[CH:19]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[C:26]1(O)C=CC=CC=1.IC>C1COCC1>[CH3:26][O:25][C:16]1[CH:15]=[C:14]([C:5]2[N:4]=[N:3][C:2]([NH2:1])=[N:7][C:6]=2[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:19]=[C:18]([O:20][C:21]([F:24])([F:22])[F:23])[CH:17]=1

Participants

5

Reactant 3

HCID 996PhenolHCID 6328Methyl iodideHCID 67363398HCID 67363398, compound

Product 1

HCID 67362736HCID 67362736, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6-(3-Methoxy-5-(trifluoromethoxy)phenyl)-5-phenyl-1,2,4-triazin-3-amine was prepared from 3-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-5-(trifluoromethoxy)phenol (100 mg, 0.287 mmol). The phenol was dissolved in THF (2 mL) and treated with iodomethane (17.87 μL, 0.287 mmol) at 0° C. After ˜15 minutes, the mixture was then allowed to warm to r.t. slowly.

Sources & evidence

ORD record
ord-73b000a4975640d18777edc5fe690890
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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